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KMID : 1159320210230040567
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Korean Journal of Vision Science
2021 Volume.23 No. 4 p.567 ~ p.575
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Zwitterion-Functionalized Hydrogel Contact Lenses for Reducing Protein and Bacteria Adsorption
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Lee Eun-Su
Kim Ho-Joong
Ryu Geun-Chang
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Abstract
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Purpose : This study is to develop hydrogel contact lenses which are surface-functionalized with zwitterionic 3-[{2-(Methacryloyloxy)ethyl}dimethylammonio] propane-1-sulfonate (DMAPS) monomers and investigate their physical properties and the reduction in protein and bacteria adsorption.
Methods : Hydrogel contact lenses were prepared by copolymerization of (2-hydroxyethyl methacrylate) HEMA and ethylene glycol dimethacrylate (EGDMA). The subsequent adsorption of benzophenone and UV-induced free radical polymerization of DMAPS monomers onto the contact lens surfaces were performed to produce the zwitterion-functionalized hydrogel contact lenses. We investigated their water contents, contact angles, optical properties, and adsorptions of protein and bacteria.
Results : The DMAPS-functionalized contact lenses have higher water content, enhanced surface wettability and good transmittance compared with the control lens. Moreover, the presence of zwitterionic DMAPS moieties at the contact lens surfaces lowered the adsorption of proteins such as lysozyme and bovin serum albumin (BSA) and reduced bacteria adsorption relative to the unmodified control.
Conclusion : The surface functionalization of hydrogel contact lenses with zwitterionic DMAPS monomers can provide a strategy for development of contact lenses which are excellent in wettability and can reduce adsorption of protein and bacteria.
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KEYWORD
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Hydrogel, Protein Adsorption, Surface-Functionalization, Wettability, Zwitterion
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